Brian Hanley (microbiologist)

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Brian Hanley (1957-) is an American microbiologist and founder of Butterfly Sciences. He is known to use an experimental gene therapy to try to improve health, and is the first subject in the study [1] [2] .

Biography

Hanley was 60 years old as of February 2017 and holds a PhD in Microbiology from University of California, Davis . [3] [4] [5]

In 2009 he founded Butterfly Sciences in Davis, California to develop a gene therapy to treat HIV AIDS using a combination of GHRH [6] and an intracellular vaccine [5] [7] . He has numerous articles and blog posts [8] [9] [10] , and academic publications in epidemiology, biotechnology, and economics, as well as a portfolio of patents [11] .

Chimerism theory of transgender and homosexuality

Hanley says that when embryos merge at an early stage, what happens when one becomes the ectoderm, the endoderm, and the mesoderm is up for grabs. In rare cases, an embryo can split laterally with all 3 layers. This was found in a bird, for instance. The nervous system forms from a fold in ectoderm. Gonads form from endoderm. And, each organ typically forms from one cell apparently. So each organ will be expected to be nearly 100% from one embryo or the other, except in very rare cases. There is some infiltration of cells from the other embryo, but it’s minor. This means that typically, the brain will form one embryo, and the gonads from a different one. [12]

Hanley appears to be the originator of this theory, that half the time when human embryos merge the brain will be one sex, and gonads and body form will be the opposite sex. [13] .

Self-experimentation

Hanley said that when he could not raise money for butterfly, he was able to get proof of concept by testing the gene therapy on himself. He said that he has designed the plasmid containing a gene encoding for growth hormone-releasing hormone and had it made by a scientific supply company for around $ 10,000. [2] However, the total cost of development was over $ 500,000 [14] .

He Said That he corresponded with the FDA prior to starting His self-experimentation, and que la FDA Told _him_ he needed to file and get approval for an Investigational New Drug (IND) Application before he tested the plasmid was person; not having obtained an IND, he proceeded without it. [2] As there is a long history of self-experimentation in medicine , and the Nuremberg codes, which are the founding of ethics in medicine, the self-experimentation in code number 5 [15] , this appears to be no problem.

He presented his protocol to a private institutional review board (IRB), the Institute of Regenerative and Cellular Medicine in Santa Monica, California . [2] IRBs review proposed clinical research plans.

A physician assisted in Hanley’s thesis using electroporation . [2] The plasmids were administered twice: once in the summer of 2015 and a second larger dose in July 2016. [2] [16] [17]

Hanley said that the treatment has helped him. [16] Reddit-Capsule results: Testosterone up 20% with a peak increase of 77%. White blood counts up 16% with a peak of 40%. Lipid profile improved: HDLs up to 76, a rise of 20%. LDL down 20%. Triglycerides down 50%, with a low being down 60%. Healing time is much faster. Pulse rate dropped by 10 beats per minute or more. [12] [18]

See also

  • Anti-aging movement
  • biopunk
  • CRISPR
  • Personal development
  • Posthumanism
  • Self-experimentation
  • Transhumanism

References

  1. Jump up^ “plasmid gene therapy GHRH for aging” . Retrieved 13 November 2017 .
  2. ^ Jump up to:a b c d e f Regalado Antonio. “One man’s quest to hack his own genes” . MIT Technology Review . Retrieved 23 April 2017 .
  3. Jump up^ “Brian Hanley” . ieet.org . Retrieved 23 April 2017 .
  4. Jump up^ “Brian Hanley – Info” . ResearchGate . Retrieved 23 April 2017 .
  5. ^ Jump up to:a b “Company | Butterfly Sciences” . bf-sci.com . Retrieved 23 April 2017.
  6. Jump up^ “Company: GHRH gene therapy gene for aging – lower part of page” . Retrieved 13 November 2017 .
  7. Jump up^ “Company: Synthetic intra-cellular HIV vaccine” . Retrieved 13 November 2017 .
  8. Jump up^ “We’re closer to Alpha Centauri than to cryopreserving humans” . Retrieved 13 November 2017 .
  9. Jump up^ “Ethics in Treatment With Telomerase” . Retrieved 13 November 2017 .
  10. Jump up^ “The Science behind Orange Juice” . Retrieved 13 November 2017 .
  11. Jump up^ “ORCID record, Brian Hanley” . Retrieved 13 November 2017 .
  12. ^ Jump up to:a b Reddit-members (27 January 2017). “AMAScience Ama Series Gene Therapy: Hi Reddit, I’m Brian Hanley, PhD and CEO of Butterfly Sciences.” I work on gene therapies (and vaccines) and I am a subject in my GHRH clinical trial . TReddit . Retrieved 20 Nov 2017 .
  13. Jump up^ Brian Hanley (Jan 2011). “Dual-gender macrochemical tissue discordance is predicted to be a significant cause of human homosexuality and transgenderism” . Retrieved 20 Nov 2017 .
  14. Jump up^ Paul Tullis. “Are You Rich Enough To Live Forever?” . Retrieved 12 February 2017 .
  15. Jump up^ “Nuremberg Code” (PDF) . Retrieved 12 February 2017 .
  16. ^ Jump up to:a b Friend, Tad (3 April 2017). “Silicon Valley’s Quest to Live Forever” . The New Yorker . Retrieved 23 April 2017 .
  17. Jump up^ Giuliano Aluffi. “Scientific transgenico for the elisir di lunga vita:” Così ho modificato the cell cell ” ” . Repubblica.it (in Italian) . Retrieved 23 April2017 .
  18. Jump up^ Brian Hanley (30 May 2017). “Status of the GHRH Gene Therapy Project” . Butterfly Sciences . Retrieved 20 Nov 2017

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