Selection shadow

The selection shadow is a concept Involved with the evolutionary theories of aging That states That selection Pressures one year individual Decrease year as individual ages and assists sexual maturity , resulting and in a “shadow” of Time Where selective fitness is not regarded. Over generations, this results in maladaptive mutations that accumulate later in life due to being non-adaptive to reproductive fitness. [1] The concept was first worked out by JBS Haldane and Peter Medawar in the 1940s, with Medawar creating the first graphical model . [1] Continue Reading

Rejuvenation Research

Rejuvenation Research is a bimonthly peer-reviewed scientific journal published by Mary Ann Liebert that covers research on rejuvenation and biogerontology . The journal was established in 1998 and the editor-in-chief is Aubrey of Gray . It is the official journal of the European Society of Preventive, Regenerative and Anti-Aging Medicine as well as PYRAMED: World Federation and World Institute of Preventive & Regenerative Medicine.

Nicotinamide mononucleotide

Nicotinamide mononucleotide (” NMN ” and ” β-NMN “) is a nucleotide derived from ribose and nicotinamide . [1] Like nicotinamide riboside , NMN is a derivative of niacin , and humans have enzymes that can be used to generate nicotinamide adenine dinucleotide (NADH). [1] Continue Reading

Methuselah-like proteins

The Methuselah-like proteins are a family of G protein-coupled receptors found in insects that play a role in aging and reproduction. Antagonizing these receptors can extend the life span of the animal and make it more resistant to free radicals and starvation, but also reduce reproduction and increase cold sensitivity. The age depends on the action and motor function is unaffected. [2] Continue Reading

Elixir of life

The elixir of life , also known as elixir of immortality and sometimes equated with the philosopher’s stone , is a potion that supposedly grants the drinker eternal life and / or eternal youth . This elixir was also said to cure all diseases. Alchemists in various ages and cultures sought the means of formulating the elixir. Continue Reading

Ending Aging

Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime is a 2007 book written by Aubrey of Gray , a biomedical gerontologist, with his research assistant Michael Rae. Ending Aging describes Gray’s proposal for eliminating aging as a cause of debilitation and death in humans, and restoring the body to an indefinitelyyouthful state, which he calls the ” Strategies for Engineered Negligible Senescence ” or “SENS”. From Gray argues that it is possible, possibly within a few decades, and it can be taken to hasten the development of regenerative medicine that will save lives. Continue Reading

Epigenetic clock

An epigenetic clock is a type of DNA clock based on measuring natural DNA methylation levels to estimate the biological age of a tissue, cell type or organ. A pre-eminent example for an epigenetic clock is Horvath’s clock , which is based on epigenetic markers on the human genome. [1] [2] [3] [4] Continue Reading

Eternal youth

Eternal youth is the concept of human physical immortality free of aging . The youth referred to is usually intended to be in contrast to the depredations of aging, rather than a specific age of the human lifespan. Achieving eternal youth so far remains beyond the capabilities of scientific technology. However, much research is being conducted in the sciences of genetics which may allow manipulation of the aging process in the future. citation needed ] Eternal youth is common in mythology, and is a popular theme in fiction . Continue Reading

Evolution of aging

Inquiry into the evolution of aging , survival success, and success of aging . Leading hypotheses [1] [2] suggest that a combination of limited resources, and an increasing risk of death by environmental causes determines an “optimal” level of self-maintenance, ie the repair of molecular and cellular level accumulates over time. Darwinian fitness is one of the most important resources of the world. In consequence, traits that improve the individual’s performance in early life are favored by selection, even if they have negative end-of-life effects when the individual has already passed on their genes to the next generation. Continue Reading

Fantastic Voyage: Live Long Enough to Live Forever

Fantastic Voyage: Live Long Enough to Live Forever (Rodale Books, ISBN 1-57954-954-3), published in 2004, is a book authored by Ray Kurzweil and Terry Grossman. The basic premise of the book is that if middle aged people can live long enough, until approximately 120, they will be able to live forever—as humanity overcomes all diseases and old age itself. This might also be considered a break-even scenario where developments made during a year increase life expectancy by more than one year. Biogerontologist Aubrey de Grey called this the “Longevity escape velocity” in a 2005 TED talk.[1] Continue Reading