Nicotinamide mononucleotide

Nicotinamide mononucleotide (” NMN ” and ” β-NMN “) is a nucleotide derived from ribose and nicotinamide . [1] Like nicotinamide riboside , NMN is a derivative of niacin , and humans have enzymes that can be used to generate nicotinamide adenine dinucleotide (NADH). [1]

Because NADH is a cofactor for processes inside mitochondria , for sirtuins , and for PARP , NMN has been studied and hyped as a potential neuroprotective and anti-aging agent. [2] [3]

References

  1. ^ Jump up to:b Bogan, KL; Brenner, C (2008). Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD + precursor vitamins in human nutrition. Annual review of nutrition . 28 : 115-30. doi : 10.1146 / annurev.nutr.28.061807.155443 . PMID  18429699 .
  2. Jump up^ Brazill, JM; Li, C; Zhu, Y; Zhai, RG (June 2017). “NMNAT: It’s an NAD + synthase … It’s a chaperone … It’s a neuroprotector”. Current Opinion in Genetics & Development . 44 : 156-162. doi : 10.1016 / j.g.2017.03.014 . PMID  28445802 .
  3. Jump up^ Stipp, David (March 11, 2015). “Beyond Resveratrol: The Anti-Aging NAD Fad” . Scientific American Blog Network .

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