Unifiram is an ampakine drug that acts as a positive allosteric modulator of the AMPA receptor , 1 which has been shown to have nootropic effects in animals. 2 3 A series of related compounds are known, one being the sunifiram (DM-235). 4 5 6 This drug has two enantiomers , with (R) – (+) – unifiram acting as more active isomer.

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